1 99:59:59,999 --> 99:59:59,999 Here's a diagram of the four chambers of the heart, so let's name them to get started. 2 99:59:59,999 --> 99:59:59,999 We've got the right atrium up here, we've got the right ventricle down here, we've got the left atrium and the left ventricle. 3 99:59:59,999 --> 99:59:59,999 These are the four chambers and blood is going to flow through all of them and get out to the body. 4 99:59:59,999 --> 99:59:59,999 So, to do this and to do this right the heart has got to coordinate how it squeezes. 5 99:59:59,999 --> 99:59:59,999 We know that the way it squeezes down is you have a cell and that cell is usually negatively charged, 6 99:59:59,999 --> 99:59:59,999 and it will at some point become more positively charged. We call that process depolarization. 7 99:59:59,999 --> 99:59:59,999 Depolarization is the idea of going from a negative membrane potential to something much more positive. 8 99:59:59,999 --> 99:59:59,999 And when you depolarize is when the muscle cell can squeeze down. 9 99:59:59,999 --> 99:59:59,999 So, where does that begin? Let's actually draw it into our diagram. 10 99:59:59,999 --> 99:59:59,999 If you were to look there's actually an area here where little cells can actually depolarize by themselves. 11 99:59:59,999 --> 99:59:59,999 And that's actually quite unique because most of the cells inside the body are going to depolarize when the neighbor, when that neighboring cell depolarizes. 12 99:59:59,999 --> 99:59:59,999 So, these are actually really unique cells because they actually depolarize by themselves. 13 99:59:59,999 --> 99:59:59,999 We call that area the sinoatrial node, sometimes called the SA node. 14 99:59:59,999 --> 99:59:59,999 And the fact that they can actually depolarize by themselves we have a word for that, too; we call that automaticity. 15 99:59:59,999 --> 99:59:59,999 It just means that they can kind of automatically depolarize without having a neighbor do it first. 16 99:59:59,999 --> 99:59:59,999 So once they depolarize, what happens after that? 17 99:59:59,999 --> 99:59:59,999 Well, when these cells depolarize they immediately, they're connected through little gap junctions to the neighboring muscle cells. 18 99:59:59,999 --> 99:59:59,999 So, they are going to start sending out waves of depolarization in all directions. 19 99:59:59,999 --> 99:59:59,999 It's almost like going to a football game and watching "The Wave" start, you know, it just goes on and on and on. 20 99:59:59,999 --> 99:59:59,999 So, all the neighboring cells are going to start depolarizing, as well. 21 99:59:59,999 --> 99:59:59,999 That orange arrow is moving kind of slowly, right? 22 99:59:59,999 --> 99:59:59,999 That depolarization wave is moving kind of slowly relative to how fast it could be moving 23 99:59:59,999 --> 99:59:59,999 if it went through a specialized band of tissue. 24 99:59:59,999 --> 99:59:59,999 So this band of tissue I'm drawing, this blue band 25 99:59:59,999 --> 99:59:59,999 is almost like a highway compared to that orange arrow, which is like a little road. 26 99:59:59,999 --> 99:59:59,999 And that highway is going to take that same depolarization wave over to the other side, 27 99:59:59,999 --> 99:59:59,999 over to the left atrium and all of these cells begin to do the same thing, they start depolarizing, as well. 28 99:59:59,999 --> 99:59:59,999 So, you get depolarizing happening both in the right atrium and the left atrium in a coordinated way. 29 99:59:59,999 --> 99:59:59,999 It's happening all very evenly. 30 99:59:59,999 --> 99:59:59,999 This band, or bundle, is called Bachmann's Bundle. It's like a bundle of tissue, right? 31 99:59:59,999 --> 99:59:59,999 It's called Bachmann's Bundle. 32 99:59:59,999 --> 99:59:59,999 So, we've named two things: the sinoatrial node and Bachmann's Bundle. 33 99:59:59,999 --> 99:59:59,999 And actually just like Bachmann's Bundle there are actually a few more bands of tissue, 34 99:59:59,999 --> 99:59:59,999 almost like little highways, that take that signal down to another node called the atrioventricular node. 35 99:59:59,999 --> 99:59:59,999 So this right here is the atrioventricular node. 36 99:59:59,999 --> 99:59:59,999 And the atrioventricular node is really the only major connection, I shouldn't even say only major, 37 99:59:59,999 --> 99:59:59,999 only connection in most of us between the atria and the ventricles, the atrioventricular node. 38 99:59:59,999 --> 99:59:59,999 And this is actually sometimes called the AV node. 39 99:59:59,999 --> 99:59:59,999 The AV node is gonna get this signal and actually I didn't even tell you what a signal came through.