1 99:59:59,999 --> 99:59:59,999 Sometimes in medicine, you'll see that words get used a lot 2 99:59:59,999 --> 99:59:59,999 and sometimes the meaning is pretty simple or straightforward and you know can be understood, 3 99:59:59,999 --> 99:59:59,999 but the words themselves can be kinda tricky and confusion. I think some of that has to do with the fact 4 99:59:59,999 --> 99:59:59,999 that these words in medicine often come from latin and so we haven't really changed the word and so, 5 99:59:59,999 --> 99:59:59,999 because latin is not a language that any of us are really familiar with and it ends up being that the term has become confusing. 6 99:59:59,999 --> 99:59:59,999 So what I'm going to do is, I'm actually gonna lay out four words for you. Starting with Chronotropy. 7 99:59:59,999 --> 99:59:59,999 And we're going to go through them one by one, basically describing what they mean. 8 99:59:59,999 --> 99:59:59,999 Chronotropy refers to the heart rate. Now as you see I've put in parentheses, a simpler way to think about these terms. 9 99:59:59,999 --> 99:59:59,999 So chronotropy has to do with heart rate. A second term is Dromotropy. And Dromotropy has to do with conduction velocity. 10 99:59:59,999 --> 99:59:59,999 How fast a signal is going from one cell to the next. And then we have Ionotropy - and Ionotropy has to do with contractility. 11 99:59:59,999 --> 99:59:59,999 How hard the muscle is contracting. The force of contraction, you can think of it as the force of contraction. 12 99:59:59,999 --> 99:59:59,999 And Lusitropy. Lusitropy has to do with the relaxation - how fast its relaxing. So, lets go through these one at a time and 13 99:59:59,999 --> 99:59:59,999 talk about the effects of the sympathetics and the parasympathetics on this. So, actually - the other thing I'm 14 99:59:59,999 --> 99:59:59,999 going to do maybe even write out where these things are primarily being effected. Where and then we'll talk about 15 99:59:59,999 --> 99:59:59,999 sympathetics and parasympathetics. Ok so where is the first one happening? So we talked about chronotropy. Of course 16 99:59:59,999 --> 99:59:59,999 its not just one cell that's going to be affected, but in general what cluster of cells are we thinking of? You're right if you're 17 99:59:59,999 --> 99:59:59,999 thinking about the SA node. Right, the SA node and this is where the heart rate is usually set. And sympathetics are 18 99:59:59,999 --> 99:59:59,999 usually going to make the SA node go and fire faster because they're going to want to allow more sodium into 19 99:59:59,999 --> 99:59:59,999 those cells, so its going to get up to the threshold for an action potential more quickly. And parasympathetics 20 99:59:59,999 --> 99:59:59,999 basically do the opposite right, they're going to let less sodium flow in, and its going to take longer to get to the 21 99:59:59,999 --> 99:59:59,999 threshold potential. So what about Dromotropy? This is a word that's maybe less commonly used, and that's why I 22 99:59:59,999 --> 99:59:59,999 want to throw it up so that you're at least familiar with at least the fact that it exists. But dromotropy has to do with 23 99:59:59,999 --> 99:59:59,999 conduction velocity so how fast is the signal being conducted through the heart. And remember for this 24 99:59:59,999 --> 99:59:59,999 the major delay ends up being in the AV node right. The huge delay sometimes, we say its a tenth of a second is in 25 99:59:59,999 --> 99:59:59,999 the AV node. So what happens in the AV node with sympathetic stimulation, well you remember when you're 26 99:59:59,999 --> 99:59:59,999 sympathetics are around they allow the calcium to come into the cell more quickly, so you actually have a faster