1 00:00:01,877 --> 00:00:03,786 So we talked about inhaling and exhaling. 2 00:00:03,786 --> 00:00:07,206 And I mentioned that the key first step for both of them is kind of 3 00:00:07,206 --> 00:00:10,374 the change in volume: going up in volume and going down in volume. 4 00:00:10,552 --> 00:00:13,239 But I didn't really talk about how that happens exactly. 5 00:00:13,239 --> 00:00:15,409 So, I'll kind of jump into that now. 6 00:00:15,600 --> 00:00:19,299 And let me begin by telling you that in the middle of your chess, 7 00:00:19,299 --> 00:00:22,424 you have this enormous kind of bone that goes down. 8 00:00:22,564 --> 00:00:25,587 I'm drawing it out of proportion just to make it very clear 9 00:00:25,587 --> 00:00:26,756 where the bone is being. 10 00:00:26,756 --> 00:00:30,550 Go ahead and feel on your own body this bone which we called 11 00:00:30,754 --> 00:00:35,541 either the breast bone or the more technical name is sternum. 12 00:00:35,736 --> 00:00:36,800 Write that down here. 13 00:00:37,028 --> 00:00:39,724 The sternum is this middle bone and 14 00:00:39,724 --> 00:00:42,784 all the ribs on both sides attached there. 15 00:00:42,960 --> 00:00:47,830 So, you've got a total of 14 ribs and 7 pairs of them. 16 00:00:47,995 --> 00:00:51,288 Actually, I should say 14 pairs of ribs. 17 00:00:51,288 --> 00:00:53,639 I don't want you to think there're 14 in total. 18 00:00:53,797 --> 00:00:57,260 There are actually 14 in total and 7 pairs of the ribs. 19 00:00:57,452 --> 00:01:03,451 So 14 ribs actually attached directly to this bone, the sternum bone. 20 00:01:03,591 --> 00:01:05,552 So in white, these are the ribs. 21 00:01:05,735 --> 00:01:07,580 And between the ribs, you actually have muscles. 22 00:01:07,856 --> 00:01:10,682 So I'm gonna draw some of these muscles between the ribs. 23 00:01:10,858 --> 00:01:14,700 And these muscles are all going to have their own nerve 24 00:01:15,233 --> 00:01:17,502 that allows them to contract. 25 00:01:17,718 --> 00:01:23,681 So, these muscles are controlled by your body or your brain. 26 00:01:23,847 --> 00:01:29,371 And their name, let me just jot down here on the side, is "intercostal muscle". 27 00:01:29,552 --> 00:01:32,843 And "inter" just means "between". So, this is the name of the muscle. 28 00:01:33,015 --> 00:01:35,914 And "costal" refers to the ribs. 29 00:01:36,087 --> 00:01:37,818 So, when you see that word "costal", 30 00:01:37,980 --> 00:01:39,217 you'll know we're talking about the ribs. 31 00:01:39,371 --> 00:01:44,121 So what's between the ribs is these muscles: intercostal muscles. 32 00:01:44,358 --> 00:01:47,858 And they're gonna start moving outwards 33 00:01:48,069 --> 00:01:50,877 when your brain says, "hey I want to take a deep breath!" 34 00:01:51,072 --> 00:01:53,717 So, these muscles are going to contract 35 00:01:53,885 --> 00:01:57,045 and the ribs are gonna move outwards. 36 00:01:57,234 --> 00:02:00,579 So these go out. And you also have... 37 00:02:00,740 --> 00:02:02,909 Let me just make a little bit of space on this xxx. 38 00:02:03,066 --> 00:02:06,336 You also have another muscle that kind of right down here. 39 00:02:06,548 --> 00:02:11,375 And it has kind of a an upside down U shape to it. 40 00:02:11,556 --> 00:02:15,275 So I'm drawing it kind of like a dome. You can think of it as a dome. 41 00:02:15,476 --> 00:02:19,147 And this dome is the floor. If you remember, 42 00:02:19,147 --> 00:02:20,995 we talked about the floor of the thorax. 43 00:02:21,189 --> 00:02:23,174 So this is of course, our diaphram muscle. 44 00:02:23,362 --> 00:02:25,510 So, you've got a diaphragm muscle. 45 00:02:25,700 --> 00:02:28,086 And this one when it contracts, it's gonna go... 46 00:02:28,267 --> 00:02:30,426 instead of going out, it's gonna go down. 47 00:02:30,614 --> 00:02:32,922 So it's gonna kind of flatten out. 48 00:02:33,104 --> 00:02:38,631 And I can actually draw this if you just stick with me for a moment. 49 00:02:38,831 --> 00:02:40,528 I'm gonna erase this dome-like shape. 50 00:02:40,704 --> 00:02:44,955 And I'm gonna draw it when it looks like as it's contract. 51 00:02:45,185 --> 00:02:47,154 So when it contracts, this is actually going to be more flat. 52 00:02:47,352 --> 00:02:53,623 And this flat diaphragm, as you can see, is now 53 00:02:53,874 --> 00:02:56,678 further down that it used to be. 54 00:02:56,832 --> 00:02:59,206 And as it goes down, all of the structures 55 00:02:59,423 --> 00:03:01,693 that are inside the space, so the two lungs, 56 00:03:01,876 --> 00:03:03,530 and of course, I didn't draw the heart here, 57 00:03:03,685 --> 00:03:05,488 but the heart would be this kind of this cardiac notch. 58 00:03:05,649 --> 00:03:08,618 If you want me to, I can even draw that heart here. 59 00:03:08,769 --> 00:03:10,164 This is our heart here. 60 00:03:10,333 --> 00:03:13,082 They're all going to kind of physically moved down. 61 00:03:13,278 --> 00:03:15,347 So this is our heart and our lungs. 62 00:03:15,611 --> 00:03:20,443 They are physically gonna be kind of drawn downwards and out. 63 00:03:20,608 --> 00:03:25,813 They're gonna also move out as the intercostal muscles move out. 64 00:03:26,002 --> 00:03:30,166 So you have expansion of these lungs, that's basically the idea. 65 00:03:30,351 --> 00:03:32,084 And if you kind of zoom in on this, 66 00:03:32,223 --> 00:03:35,015 to kind of see exactly what this expansion looks like, 67 00:03:35,247 --> 00:03:38,198 when I say, you know, you have more volume, the lungs, 68 00:03:38,346 --> 00:03:41,573 really what I should be saying, if I want to be more exact, 69 00:03:41,710 --> 00:03:45,496 is that all the alveoli, if these are the alveoli, 70 00:03:45,684 --> 00:03:46,819 let's say this is another branch, 71 00:03:47,016 --> 00:03:48,411 this is another alveolar right here; 72 00:03:48,589 --> 00:03:52,300 all these alveoli, they are actually expanding. 73 00:03:52,435 --> 00:03:56,631 And you have about 500 million alveoli. 74 00:03:56,769 --> 00:03:59,383 You can just kind of fathom how big a number that it is. 75 00:03:59,553 --> 00:04:01,237 It's an enormous number of alveoli. 76 00:04:01,400 --> 00:04:05,925 If I was actually drawing them here... drawing forever, right? 77 00:04:06,071 --> 00:04:08,878 It'll take forever to kind of write out this many different alveoli. 78 00:04:09,034 --> 00:04:12,371 But basically what happens is that, when the ribs go out, 79 00:04:12,527 --> 00:04:13,505 the diaphragm moves down. 80 00:04:13,663 --> 00:04:19,933 These alveoli are actually being pulled out. They are actually pulled outwards. 81 00:04:20,113 --> 00:04:23,417 So they are actually gonna be getting larger in size. 82 00:04:23,417 --> 00:04:25,304 They literally look like they've grown in size. 83 00:04:25,442 --> 00:04:28,269 And, this is what they look like. 84 00:04:28,401 --> 00:04:31,175 And actually, if you take even a closer look, 85 00:04:31,344 --> 00:04:35,986 you'll see that these alveoli have around them, a bunch of protein. 86 00:04:36,240 --> 00:04:38,242 The cells around them have a bunch of protein. 87 00:04:38,431 --> 00:04:41,629 And this protein is called "elastin". 88 00:04:41,755 --> 00:04:45,382 And you can guess what elastin might do. 89 00:04:45,521 --> 00:04:48,777 It has kind of a similar sound to the word "elastic". 90 00:04:49,066 --> 00:04:52,525 Elastin is basically kind of like a rubber band. 91 00:04:52,664 --> 00:04:55,796 So you kind of thinking of elastin as a rubber band. 92 00:04:55,948 --> 00:05:00,035 And, when the muscles move down and out, 93 00:05:00,224 --> 00:05:03,210 and the alveoli pulled open, 94 00:05:03,371 --> 00:05:05,247 let me actually kind of scroll up, 95 00:05:05,410 --> 00:05:07,726 because you can kind of go back to the idea of inhaling. 96 00:05:07,879 --> 00:05:10,639 What is happening? Well, we have a couple things happening. 97 00:05:10,810 --> 00:05:17,419 One, you have muscles contracting. Muscles contract. 98 00:05:17,735 --> 00:05:20,015 And when I say "muscles", you know I'm talking about 99 00:05:20,171 --> 00:05:21,932 all those intercostal muscles in your diaphragm. 100 00:05:22,122 --> 00:05:24,692 And as a result of the muscles contracting, 101 00:05:24,853 --> 00:05:30,269 you have now the alveoli, alveoli are streched open. 102 00:05:30,435 --> 00:05:33,527 So those rubber bands are elastin, protein, 103 00:05:33,767 --> 00:05:36,283 are literally physically being stretched open. 104 00:05:36,467 --> 00:05:39,203 So the alveoli are stretched open. 105 00:05:39,383 --> 00:05:45,386 And keep that in mind, because what's gonna happen then is, 106 00:05:45,632 --> 00:05:48,855 when the muscles relax, which is what happens when you exhale, 107 00:05:49,022 --> 00:05:50,883 when the muscles relax, 108 00:05:51,066 --> 00:05:54,158 what do you think is going to happen to that elastin? 109 00:05:54,158 --> 00:05:55,360 Well, it's like a rubber band, 110 00:05:55,518 --> 00:05:56,926 if that's what I'm saying, it's gonna be like, 111 00:05:57,085 --> 00:06:01,828 then the alveoli are going to recoil. They are gonna recoil. 112 00:06:01,973 --> 00:06:06,859 And that's actually the driving force for why the volume goes back down. 113 00:06:07,037 --> 00:06:09,661 So if you have a bunch of rubber bands that you're stretching out... 114 00:06:09,835 --> 00:06:12,171 Let me actually bring up the picture so you'll see really clearly. 115 00:06:12,355 --> 00:06:17,367 If you're physically kind of using your muscles to help pull this stuff open, 116 00:06:17,534 --> 00:06:22,198 then the moment that you start pulling open, the moment that you, 117 00:06:22,380 --> 00:06:24,651 you know, stop contracting those muscles, 118 00:06:24,932 --> 00:06:26,203 now you have a nice big volume. 119 00:06:26,421 --> 00:06:28,013 What's gonna happen? 120 00:06:28,165 --> 00:06:31,915 All these elastin molecules are gonna snap back. 121 00:06:32,120 --> 00:06:33,218 We'll do it with a different color. 122 00:06:33,427 --> 00:06:34,937 I'll do it with this color. 123 00:06:35,097 --> 00:06:37,374 They are gonna snap back like this. 124 00:06:37,576 --> 00:06:42,766 All that protein are gonna snap back into kind of the original size. 125 00:06:42,940 --> 00:06:45,234 And when they do, this thing gets smaller. 126 00:06:45,373 --> 00:06:48,552 So my alveoli kind of goes back to its original size, 127 00:06:48,522 --> 00:06:50,298 which is much smaller than this. 128 00:06:50,476 --> 00:06:53,765 Let me actually show you that 129 00:06:53,930 --> 00:06:56,815 even though contraction is what opens up things 130 00:06:57,008 --> 00:07:01,494 it's the recoil that kind of brings things back down to their normal size. 131 00:07:01,754 --> 00:07:05,019 Let me erase this to make it kind of neater drawing. 132 00:07:05,158 --> 00:07:09,185 So you can see it now, inhaling, the way that we actually increase the volume, 133 00:07:09,336 --> 00:07:12,098 is by pulling things open through contraction. 134 00:07:12,250 --> 00:07:16,161 And this actually requires energy, right? 135 00:07:16,302 --> 00:07:20,380 Remember, you can't contract a muscle without spending chemical energy. 136 00:07:20,628 --> 00:07:22,532 So this takes chemical energy. 137 00:07:22,729 --> 00:07:25,837 And we usually think of this molecule ATP 138 00:07:26,100 --> 00:07:29,921 as the specific type of chemical energy we're gonna use. 139 00:07:30,118 --> 00:07:33,707 And to exhale, when you reduce the volume, 140 00:07:33,837 --> 00:07:37,034 it's gonna be driven by this elastic recoil. 141 00:07:37,200 --> 00:07:42,308 So that's a type of elastic potential energy. 142 00:07:42,657 --> 00:07:48,283 So, this process of kind of inhaling and exhaling 143 00:07:48,474 --> 00:07:50,292 is really a little different from each other. 144 00:07:50,440 --> 00:07:52,518 On the one hand, you're using ATP; 145 00:07:52,742 --> 00:07:54,489 you're actually burning through these molecules. 146 00:07:54,646 --> 00:07:55,960 And when you exhale, 147 00:07:56,118 --> 00:07:58,666 you're actually not using chemical energy anymore. 148 00:07:58,841 --> 00:08:01,210 You're just using that elastic potential energy, 149 00:08:01,420 --> 00:08:04,005 kind of the same sort of energy that you can imagine 150 00:08:04,196 --> 00:08:06,753 you would have if you snap a rubber band. 151 00:08:06,753 --> 00:08:09,392 So, let's stop there. We'll pick up the next video.