1 00:00:02,239 --> 00:00:06,509 I wanna figure out how blood gets from my heart, which I'm going to draw here, 2 00:00:06,509 --> 00:00:13,201 all the way to my toe, and I'm going to draw my foot over here and show you which toe I'm talking about. 3 00:00:13,201 --> 00:00:15,933 Let's say this toe right here. 4 00:00:15,933 --> 00:00:24,037 Now, to start the journey, it's gonna have to out of the left ventricle and into the largest artery of the body. 5 00:00:24,037 --> 00:00:31,602 This is going to be the aorta, and the aorta is very, very wide across, and that's why I say it's a large artery. 6 00:00:31,602 --> 00:00:35,905 And, from the aorta, I'm actually not drawing all the branches of the aorta, 7 00:00:35,905 --> 00:00:44,876 but from the aorta, it's going to go down into my belly, and it's going to branch towards my left leg and my right leg. 8 00:00:44,876 --> 00:00:48,407 So, let's say we follow just the left leg, 9 00:00:48,407 --> 00:00:50,742 so this artery over here on the top, 10 00:00:50,742 --> 00:00:56,504 it's gonna get a little bit smaller, and maybe I would call this a medium-sized artery by this point. 11 00:00:56,504 --> 00:01:00,037 Ah, this is actually now getting down towards my ankle. 12 00:01:00,037 --> 00:01:04,004 Let's say we've gone quite a distance down to my ankle, 13 00:01:04,004 --> 00:01:09,369 and then, you know there are, of course, little branches, and let's just follow the branch that goes towards my foot, 14 00:01:09,369 --> 00:01:10,500 which is this top one. 15 00:01:10,500 --> 00:01:12,232 Let's say this one goes towards my foot, 16 00:01:12,232 --> 00:01:15,200 and this is going to be now an even smaller artery. 17 00:01:15,200 --> 00:01:17,109 Let's call it small artery. 18 00:01:17,109 --> 00:01:19,235 Small artery. 19 00:01:20,481 --> 00:01:21,956 From there, 20 00:01:21,956 --> 00:01:25,836 we're actually going to get into what we call arterioles. 21 00:01:25,836 --> 00:01:28,803 So it's going to get even tinier, right? It's going to branch. 22 00:01:28,803 --> 00:01:34,703 Now, these are very, very tiny branches coming off of my small artery, and let's follow this one right here, 23 00:01:34,703 --> 00:01:37,036 and this one is my arteriole. 24 00:01:37,036 --> 00:01:38,470 Arteriole. 25 00:01:38,470 --> 00:01:42,290 So, these are all the different branches I have to go through, 26 00:01:42,290 --> 00:01:46,475 and finally, I'm going to get into tiny little branches, 27 00:01:46,475 --> 00:01:51,136 I'm going to have to draw them very, very skinny just to convince you that we're getting smaller and smaller. 28 00:01:51,136 --> 00:01:53,285 Let me draw three of them. 29 00:01:53,285 --> 00:01:56,970 Nah, let's draw four, just for fun. Ah, four of them, 30 00:01:56,970 --> 00:02:05,636 and this is actually gonna now get towards my little toe cells, so let me draw some toe cells in here to convince you that I actually have gotten there. 31 00:02:05,636 --> 00:02:10,969 Let's say one, two over here, and maybe one over here, and these are my toe cells. 32 00:02:10,969 --> 00:02:12,451 Toe cells. 33 00:02:12,451 --> 00:02:16,617 And after the toe cells have kind of taken out whatever they need. 34 00:02:16,617 --> 00:02:19,803 Maybe they need glucose, or maybe they need some oxygen. 35 00:02:19,803 --> 00:02:21,070 Whatever they have taken out, 36 00:02:21,070 --> 00:02:24,470 they are also gonna put in their wastes, 37 00:02:24,470 --> 00:02:28,619 so they have, of course, some carbon dioxide waste that we need to drag back. 38 00:02:28,619 --> 00:02:33,536 This is now going to dump into what we call a venule. 39 00:02:33,536 --> 00:02:34,781 A venule, 40 00:02:34,781 --> 00:02:38,970 and this venule is gonna basically then feed into many, many other venules. 41 00:02:38,970 --> 00:02:43,446 Maybe there's a venule down here coming in, and maybe a venule up here coming in. 42 00:02:43,446 --> 00:02:45,100 Maybe from the second toe, 43 00:02:45,100 --> 00:02:47,869 and it's gonna basically all kind of gather together, 44 00:02:47,869 --> 00:02:50,797 and again, to a giant, giant set of veins. 45 00:02:50,797 --> 00:02:54,469 You know, maybe veins are dumping in here now, maybe another vein dumping in here, 46 00:02:54,469 --> 00:03:02,031 and these veins are all going to dump into an enormous vein that we call the inferior vena cava. 47 00:03:02,031 --> 00:03:03,036 I'll write that right here. 48 00:03:03,036 --> 00:03:05,776 Inferior vena cava, 49 00:03:05,776 --> 00:03:12,308 and this is the large vein that brings back all the blood from the bottom half of the body. 50 00:03:12,308 --> 00:03:16,036 There's also another one over here called the superior vena cava, 51 00:03:16,036 --> 00:03:19,868 and this is bringing back blood from the arms and head. 52 00:03:19,868 --> 00:03:26,868 So these two veins, the superior vena cava and the inferior vena cava, are dragging the blood back to the heart, 53 00:03:26,868 --> 00:03:30,636 and, generally speaking, these are all considered, of course, veins. 54 00:03:30,636 --> 00:03:34,005 Let's back up now and start with the large and medium arteries. 55 00:03:34,005 --> 00:03:39,137 These guys together are sometimes referred to as elastic arteries. 56 00:03:39,137 --> 00:03:40,797 Elastic arteries, 57 00:03:40,797 --> 00:03:42,804 and the reason they're called elastic arteries, 58 00:03:42,804 --> 00:03:50,470 one of the, one of the good reasons why they're called that is that they have a protein in the walls of the blood vessel called elastin. 59 00:03:50,470 --> 00:03:53,119 They have a lot of this elastin protein, 60 00:03:53,119 --> 00:03:56,737 and, if you think about the word elastin or elastic, 61 00:03:56,737 --> 00:03:58,947 you know, obviously similar words, 62 00:03:58,947 --> 00:04:02,369 you might think of something like a rubber band or a balloon, 63 00:04:02,369 --> 00:04:04,469 and that's probably the easiest way to think about it. 64 00:04:04,469 --> 00:04:08,470 If you have a blood vessel, one of these large arteries for example, 65 00:04:08,470 --> 00:04:16,837 and let's say blood is under a lot of pressure, right, because the heart is squeezing out a lot of high pressure blood. 66 00:04:16,837 --> 00:04:21,669 This artery is literally going to balloon out, and if you actually looked at it from the outside, 67 00:04:21,669 --> 00:04:24,069 it would look like a little sausage. 68 00:04:24,069 --> 00:04:26,941 Something like this, where it's puffed out. 69 00:04:26,941 --> 00:04:33,529 So what's happened there between the first and second picture is that the pressure energy, 70 00:04:33,529 --> 00:04:38,869 so the heart is squeezing out a lot of pressurized blood, and of course, there's energy in that blood, right? 71 00:04:38,869 --> 00:04:44,469 That pressure energy has been converted over into elastic energy. 72 00:04:44,469 --> 00:04:49,511 It's actually converting energy. We don't really always think about it that way, but that's exactly what's happening, 73 00:04:49,511 --> 00:04:52,694 and when you convert from pressure energy to elastic energy, 74 00:04:52,694 --> 00:04:57,203 what you are really then doing is you're balancing out those high pressures. 75 00:04:57,532 --> 00:05:00,887 So you're balancing out high pressures. 76 00:05:00,964 --> 00:05:02,411 High pressures, 77 00:05:02,411 --> 00:05:10,661 and this is actually very important because the blood that's coming into our arteries is under, let's not forget, high pressure. 78 00:05:10,661 --> 00:05:14,631 So the arteriole system, we know, is a high pressure system. 79 00:05:14,631 --> 00:05:20,734 So this makes perfect sense that the first few arteries, those large arteries and even those medium-sized arteries 80 00:05:20,734 --> 00:05:23,662 are going to be able to deal with the pressure really well. 81 00:05:23,662 --> 00:05:26,327 Now let me draw a little line here just to keep it straight. 82 00:05:26,327 --> 00:05:33,994 The small artery and the arteriole, these two, these are actually sometimes called the muscular arteries. 83 00:05:33,994 --> 00:05:35,428 Muscular arteries, 84 00:05:35,428 --> 00:05:41,994 and the reason, again, if you just want to look at the wall of the artery, you'll get the answer. 85 00:05:41,994 --> 00:05:45,496 The wall of the artery is actually very muscular. 86 00:05:45,496 --> 00:05:47,806 In fact, specifically, it's smooth muscle. 87 00:05:47,806 --> 00:05:54,196 So not that kind of muscle you have in your heart or in your bicep, but this is smooth muscle 88 00:05:54,196 --> 00:05:57,357 that's in the wall of the artery, and there's lots of it. 89 00:05:57,357 --> 00:06:03,626 So again, if you have a little blood vessel like this, if you imagine tons and tons of smooth muscle on the outside, 90 00:06:03,626 --> 00:06:05,028 so let's draw it like this. 91 00:06:05,028 --> 00:06:07,161 Little bands of smooth muscle. 92 00:06:07,161 --> 00:06:11,290 If those bands decide that they want to contract down, if they want to squeeze down, 93 00:06:11,290 --> 00:06:16,626 you're going to get something that looks like a little straw because those muscles are now tight. 94 00:06:16,626 --> 00:06:18,623 They are tightly wound, right? 95 00:06:18,623 --> 00:06:23,657 So you're going to create like a little straw, and this process is called vasoconstriction. 96 00:06:23,657 --> 00:06:29,395 Vaso- just means blood vessel, and constriction is, kinda, tightening down. 97 00:06:29,395 --> 00:06:36,559 So vasoconstriction, tightening down of the blood vessel, and what that does is it increases resistance, right? 98 00:06:36,559 --> 00:06:41,470 Just like if you're trying to blow through a tiny, tiny little straw, there's a lot of resistance. 99 00:06:41,470 --> 00:06:51,393 Well, it's the same idea here, and actually a lot of that resistance and change in the constriction, or vasoconstriction, is happening at the arteriole level. 100 00:06:51,393 --> 00:06:53,972 So that's why they're very special, and I want you to remember them. 101 00:06:53,972 --> 00:06:56,662 From there, blood is going to go through the capillaries. 102 00:06:56,662 --> 00:06:59,061 I didn't actually label them the first time, but let me just write that here. 103 00:06:59,061 --> 00:07:01,090 Sometimes, they call them capillary beds. 104 00:07:01,090 --> 00:07:03,153 I'll write that out, 105 00:07:03,153 --> 00:07:07,834 and then it's going to go and get collected in the venules and eventually into the veins, 106 00:07:07,834 --> 00:07:10,027 and the important thing about the veins, 107 00:07:10,027 --> 00:07:14,765 I'm going to stop right here and just talk about it very briefly, is that they have these little valves, 108 00:07:14,765 --> 00:07:18,761 and these valves make sure that the blood continues to flow in one direction. 109 00:07:18,761 --> 00:07:22,475 So one important thing here is the valves, 110 00:07:22,475 --> 00:07:26,725 and remember the other important thing is that they are able to deal with large volumes. 111 00:07:26,725 --> 00:07:30,994 So unlike the arteriole side, where it's all about large pressure, 112 00:07:30,994 --> 00:07:34,826 down here with the vein side, we have to think about large volumes. 113 00:07:34,826 --> 00:07:38,826 Remember, about two-thirds of your blood at any point in time is sitting in some vein or venule somewhere.